FRONTIER BIOTECHNOLOGIES Inc.

Products

Frontier Biotechnologies Inc.(Nanjing)
Home>Products

FB2001

  • 2022-07-05  13:09:54

FB2001 (generic name: Bofutrelvir) is a SARS-CoV-2 3CL protease inhibitor under clinical development for hospitalized patients as well as for post-exposure prophylaxis of Covid-19.  It is a peptidomimetic compound targeting 3CL-protease based on three-dimensional crystal structure of the protease.  Preclinical data has shown it has potent activities in vitro and in vivo against SARS-CoV-2 variants such as Alpha, Beta, Delta, and Omicron.  Clinical data from two phase 1 trials conducted in the US and China has shown that Bofutrelvir is safe and tolerable with a PK profile (without using a booster like ritonavir) supporting further clinical development.  It is currently in a pivotal global phase 2/3 clinical trial for hospitalized Covid-19 patients.

Develop Innovative Therapies to Better Human Lives